Guide To The Causes And Treatment Of Sideroblastic Anemia

Chelating Agents

Chelating agents are often used in the treatment regimen for an individual affected by sideroblastic anemia to reduce symptoms and complications that may occur from iron overload. Because the cells in sideroblastic anemia patients are unable to synthesize iron into hemoglobin, the iron sits and builds up inside of the blood cells. Iron meets the capacity of blood cells and ferritin, causing it to build up in other tissues around the body. This buildup is problematic because free iron deposits can cause the formation of toxic and damaging compounds. Chelating agents can be administered to protect the cells of an individual's bodily tissues from iron toxicity. Chelating agents work by binding to the form of iron that is toxic to bodily tissues. This iron may be referred to as free iron, as it is not bonded to ferritin in the individual's blood, and is free to elicit toxic reactions. Chelating agents bind to all of the iron's electrochemical coordination sites that allow for its volatile reactions in bodily tissues. This mechanism causes the free iron to become inactivated until the body can break it down.

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