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Causes & Risk For Eosinophilic Esophagitis

By

HealthPrep Staff

Multiplication Of The Eosinophils

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Eosinophils are formed in the bone marrow and are then released into the bloodstream, though they are not supposed to multiply. When there is the multiplication of the eosinophils, they secrete substances including eosinophil protein X, eosinophilic cationic protein, major basic protein, eosinophil peroxidase, TGF-β, and eosinophil-derived neurotoxin. These substances not only damage the cells in the esophagus but also activate bodies called mast cells, which are other kinds of white blood cells that release compounds that further damage the esophageal tissue. TGF-β is one of the main culprits in causing the esophagus to become dangerously narrow and dysfunctional.

Keep reading to learn more about the causes and risk factors of eosinophilic esophagitis.

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